Andy Samberg

Ham III (voice)

Cheryl Hines

Luna (voice)

Jeff Daniels

Zartog (voice)

Patrick Warburton

Titan (voice)

Kristin Chenoweth

Kilowatt (voice)

Kenan Thompson

Ringmaster (voice)

Zack Shada

Comet / Nava Boy (voice)

Carlos Alazraqui

Houston (voice)

Omid Abtahi

Dr. Jagu (voice)

Patrick Breen

Dr. Bob (voice)

Jane Lynch

Dr. Poole (voice)

Kath Soucie

Dr. Smothers (voice)

Stanley Tucci

Senator (voice)

Wally Wingert

Splork / Infinity Probe / Pappy Ham (voice)

Jessica Gee-George

Ship Voice / Infinity Probe / Additional Voices (voice)