Jenifer Lewis

Jackie Washington

Tim Curry

Edward Whatsett St. John

T.V. Blake

Antandra Washington (Jackie's Daughter)

Tangie Ambrose

Shaniqua Summers Wells (Jackie's Daughter)

Whoopi Goldberg

Nurse Ethyl Washington Rue Owens (Jackie's Sister)

Robert Bailey Jr.

Wilson Wells (Jackie's Grandson)

Tom Arnold

Marvin Pritz (Jackie's Former Manager)

Loretta Devine

Snookie Tate (Jackie's Childhood Friend)

Julie Hagerty

Pammy Dunbar (Infomercial Host)

David Hyde Pierce

Perry (The Deaf Rehearsal Pianist)

Kathy Najimy

Lola Molina (Jackie's Stalker)

Isabel Sanford

Miss Krumes (Jackie's Play Mama)

JoBeth Williams

Jo Face (Jackie's Vocal Coach)

Mary Wilson

Vesta Crotchley (Jackie's Third Grade Teacher)

Reynaldo Rey

Cadillac Johnson (Retired Pimp)