E. G. Daily

Tommy Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Kath Soucie

Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cree Summer

Susie Carmichael / Edwin Carmichael (voice)

Dionne Quan

Kimi Finster (voice)

Ron Glass

Randy Carmichael (voice)

Irma P. Hall

Aunt T. (voice)

Crystal Scales

Buster Carmichael (voice)

Hattie Winston

Lucy Carmichael / Lucy's Mom (voice)

Kimberly Brooks

Young Lucy (voice)

Bill Cobbs

Uncle Charles (voice)

Kevin Michael Richardson

Martin Luther King Jr. (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)