Steve Carell

Gru (voice)

Kristen Wiig

Lucy (voice)

Benjamin Bratt

Eduardo / El Macho (voice)

Miranda Cosgrove

Margo (voice)

Dana Gaier

Edith (voice)

Elsie Fisher

Agnes (voice)

Russell Brand

Dr. Nefario (voice)

Ken Jeong

Floyd (voice)

Steve Coogan

Silas (voice)

Moisés Arias

Antonio (voice)

Nasim Pedrad

Jillian (voice)

Kristen Schaal

Shannon (voice)

Pierre Coffin

Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice)

Chris Renaud

Additional Minions / Evil Minions / Italian Waiter (voice)

Nickolai Stoilov

Arctic Lab Guards (voice)